TP53 and neoplasm: The data is of clinical relevance as the efficiency of several chemo‐ and radiotherapies has been suggested to be principally p53 tumor suppressor gene dependent in many cases [47] which in turn has been proven to be regulated by high‐risk HPV E6 protein expression [48, 49] or dependent of histone deacetylases (HDAC) like SirT1 expression dependent [50].