Although the importance of genetic alterations in p53 gene has been reported to be associated with cancer of other aetiologies like stomach cancer [18], lung cancer [19] and nasopharyngeal carcinoma [20] in northeast Indian population, but no reports exists for its association with CaCx pathogenesis in the ethnically distinct northeast Indian population majorly comprising population of tribal dominance eg Bodos, Kacharis, Karbis, Dimasas, Tiwa and Lalungs etc. Presented herein is a study involving northeast Indian population for the significance of p53 signatures in the pathogenesis of CaCx. The gene discussed is TP53; the disease is lung carcinoma.