The results on the p53 acetylation changes and resulting expression in CaCx cases is also important because p53 acetylation in response to virus infection has been documented as an indispensable event for the transcriptional activation of p53-dependent genes in reaction to viral infection and the successive control of virus replication [52] which is mainly mediated by activation of the interferon pathway [53]. The gene discussed is TP53; the disease is viral infectious disease.