The data so obtained was interesting which showed that in HPV negative cervical cancer the expression of p53 was upregulated for Arg/arg and Arg/Pro genotype compare to Pro/Pro whereas for in HPV positive cervical cancer the results were completely contrasting showing downregulation in p53 expression for Arg/Arg and Arg/Pro compare to Pro/Pro genotype. This evidence concerns the gene TP53 and cervical cancer.