TP53 and neoplasm: The data for p53 downregulation in HPV infected cervical cancer cases with different severity grade also showed a variation with significant downregulation in lower severity grades compare to higher severity grades indicating the association of deregulated P53 expression in the early stage of cervical cancer cases leading to the pathogenesis of the diseases which relates with the study of Liu et al. [27], who suggested that p53 is associated in the development and metastasis of cervical cancer by promoting tumor cell infiltration.