In addition, the level of IgE, IgG1 and IL-4, but not IgG2a and IFN-γ, in NLRP3-/- mice immunized by rTs-Serpin + lentinan was significantly decreased compared with WT mice, indicating NLRP3 participated in lentinan–induced protective efficacy through modulating Th2 immune response, which is associated with protective immunity to parasite infection. Here, NLRP3 is linked to parasitic infectious disease.