IGHE and parasitic infectious disease: In addition, the level of IgE, IgG1 and IL-4, but not IgG2a and IFN-γ, in NLRP3-/- mice immunized by rTs-Serpin + lentinan was significantly decreased compared with WT mice, indicating NLRP3 participated in lentinan–induced protective efficacy through modulating Th2 immune response, which is associated with protective immunity to parasite infection.