FAP and myocardial ischemia: This is of particular relevance considering that following myocardial injury due to myocardial ischemia, FAP-α has been shown to be enriched in adjacent myocardium (close to infarcted myocardium, with reduced function and perfusion) compared to remote myocardium (preserved function and perfusion) in a pig model of myocardial infarction.5 This leads to the hypothesis that visualization of FAP expression could help to assess the extent of myocardial damage following MI in progressive CAD and to further assess the extent of cardiac re-modeling following such ischemic events.