ERBB2 and neoplasm: The use of the anti-HER2 monoclonal antibody trastuzumab for 1 year, along with chemotherapy, is now standard of care for tumours with a size of 5 mm or greater and for tumours of any size with nodal involvement, based on the substantial disease-free and overall survival benefits that have been reported when compared with the use of chemotherapy alone (disease-free survival, hazard ratio for recurrence 0.60, 95% CI 0.50–0.71; overall survival, hazard ratio for mortality 0.66, 95% CI 0.57–0.77) [45].