APC and osteoporosis: Tested by MTT assay, PI single staining and Annexin V‐APC/PI double staining, it was investigated that (Figure 7A‐E) in osteoblasts, viability was impaired and apoptosis rate was boosted (more G0/G1 and less S and G2/M phases cells) in osteoporosis rats (all P < 0.05).