LRG1 and osteoporosis: RT‐qPCR and Western blot analysis (Figure 2A‐D) demonstrated that in bone tissues, miR‐497 expression down‐regulated while LRG1 expression elevated in the osteoporosis rats in comparison with the normal SD rats (all P < 0.05), indicating the involvements of miR‐497 and LRG1 in osteoporosis.