In conclusion, our study reveals that miR‐497 is down‐regulated and LRG1 is upregulated in osteoporosis, and the increased miR‐497 or decreased LRG1 acts to alleviate the progression of osteoporosis via activating TGF‐β1/Smads pathway (Figure 8). The gene discussed is LRG1; the disease is osteoporosis.