Riveting on our findings, up‐regulation of miR‐497 or down‐regulation of LRG1 could activate TGF‐β signalling pathway as accompanied by increased TGF‐β1, Smad3, Smad4 and p‐Smad2/3 protein expression and reduced Smad7 protein expression in osteoporosis. Here, SMAD4 is linked to osteoporosis.