Given that, this study is initiated and elucidates that up‐regulation of miR‐497 or down‐regulation of LGR1 promoted osteoporosis osteoblast viability, enhanced collagen synthesis and inhibited osteoblast apoptosis, which may be connected with the activation of TGF‐β1/Smads signalling pathway. The gene discussed is FSHR; the disease is osteoporosis.