To dissect the TF regulatory circuitry underlying the heterogeneity of GBM and construct a model that facilitates generation of actionable hypotheses for targeting different GBM subtypes, we integrated multiple lines of data and assembled a novel computational pipeline, Integrative Modeling of Transcription Regulatory Interactions for Systematic Inference of Susceptibility in Cancer (inTRINSiC). Here, TF is linked to glioblastoma.