Importantly, it has been shown that the transcription factor STAT3 (a Proneural/Mesenchymal signature TF inferred by inTRINSiC) and its associated signaling network play key roles in promoting an immunosuppressive tumor microenvironment that may hinder immunotherapy (See et al, 2012; Jackson et al, 2011). The gene discussed is TF; the disease is neoplasm.