We first showed that transcription regulation by TFs can be quantitatively described using biophysical models, which despite simplifying assumptions was still able to accurately capture gene expression variation across GBM subtypes (Figs 1C and EV1C) as well as TF‐TF co‐regulatory interactions (Fig 2C and D), which are not explicitly factored into the model. Here, TF is linked to glioblastoma.