TF and glioblastoma: We estimated F values for each TF‐gene pair in each GBM subtype by fitting the regression model to subtype‐specific expression profiles in the TCGA GBM dataset and imposing an L2‐like regularization term that penalizes large absolute values of parameters and prevents overfitting, and used 5‐fold cross‐validation to select the best hyperparameters for regularization strength (Fig EV1C).