TF and glioblastoma: Specifically, we found that despite conservation of the majority of TF‐TF partnering relationships (Fig EV2A), TFs that are part of a subtype signature tend to display local, differential partnering with other TFs across proximal regulatory regions of target genes, implying that the regulatory heterogeneity observed across GBM subtypes may be a result of differential physical clustering of TFs at promoters/enhancers.