In conclusion, damoctocog alfa pegol had a superior PK profile compared with rurioctocog alfa pegol, including a higher AUCnorm (based on potency-adjusted analyses), extended half-life, and a longer median time to reach 1% IU/dL FVIII (based on popPK modeling) following a single infusion in patients with severe hemophilia A. This evidence concerns the gene F8 and hemophilia A.