This is due to the criteria that weimposed at the onset of the study—that the subjects be matched for age and sex, that allhave CAA, that none have non-AD pathology, and that they cover the CDR scores scale.Apolipoprotein E4 allele (APOE4) allele happened to bepresent in some AD subjects but not in any of non-AD subjects. This evidence concerns the gene APOE and Alzheimer disease.