Our current data and published results (Adams et al.2018) showing concomitant changes in vascular and neuronal ALK1 expression duringAD progression are in line with our previous studies documenting simultaneous neuronal andarteriolar abnormalities in the expression of methionine sulfoxide reductase B3 (MSRB3) inhippocampi of AD patients (Adams et al. This evidence concerns the gene ACVRL1 and Alzheimer disease.