Hippocampal arteriolar wall ALK1 signal intensity was 35% lower in AD patients(Braak and Braak Stages IV and V [BBIV-V]; clinical dementia rating [CDR1-2]) as comparedwith subjects with early AD pathologic changes but either cognitively intact or withminimal cognitive impairment (BBIII; CDR0-0.5). The gene discussed is ACVRL1; the disease is Alzheimer disease.