Considering that PRV EP0 and its homologous protein HSV-1 ICP0 can be transported between the cytoplasm and nucleus (46, 51) and that ICP0 influences numerous host nuclear proteins, such as cyclin D3, p53, ND10, p60, and the ubiquitin-specific protease USP7, in addition to regulating viral gene expression, stimulating lytic infection, and enhancing reactivation of latent infection (52–57), we reasonably assumed that VP11/12 might exhibit connections with the functions of EP0 in the nucleus. Here, USP7 is linked to disease arising from reactivation of latent virus.