TFCP2 and cancer: The LSF/CP2 subfamily has three mammalian orthologs and evolved from the ancestral gene gemini (dCP2) in Drosophila. Recent critical reviews have discussed the role of LSF/CP2 subfamily members (TFCP2, TFCP2L1, and UBP1) in various aspects of development and human diseases including cancer (Kotarba et al., 2018; Taracha et al., 2018).