In ovarian cancer, using experimental ChIP-seq data derived from five major histone marks (H3K4me3, H3K4me1, H3K9me3, H3K27me3, and H3K27ac), our group has utilized this pipeline to show that upon the loss of GRHL2, a radical shift from an active chromatin state toward a latent, poised/bivalent, or repressed chromatin state occur across intronic and intergenic regions at the GRHL2 binding sites of epithelial genes such as MARVELD3, ESRP1, GRHL1, RAB25, OVOL2 and MUC20 (Chung et al., 2019). Here, OVOL2 is linked to ovarian cancer.