GRHL2 and breast carcinoma: At the molecular level, GRHL2 directly regulates the expression of the EGFR family member ERBB3 and the Wnt ligand Wnt7A, and overexpression of GRHL2 in metastatic breast cancer cells exhibit increased anchorage-independent growth, migratory and invasive potential (Xiang et al., 2012; Werner et al., 2013).