The principal NR studied in NAFLD/NASH are liver X receptor (LXR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor-gamma (PPARγ), Farnesoid X receptor (FXR), and HNF4α, hepatocyte nuclear factor 4α (185–189). This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatohepatitis.