NR1I2 and metabolic dysfunction-associated steatotic liver disease: Many other specific BA-activated receptors, including members of the nuclear receptor superfamily (FXR, NR1H4), a vitamin D receptor (NR1I1), PXR (NR1I2), members of the G protein–coupled receptor superfamily (TGR5 and sphingosine 1 receptor 2), and transporters such as ileal apical sodium-dependent bile acid transporter (ASBT), have a role in insulin sensitivity and NAFLD pathogenesis and are a target for novel therapies.