Alcohol consumption and obesity (BMI ≥30) showed a synergistic association with the risk of incident HCC in both unadjusted analyses (HR = 7.19, 95% CI: 3.69, 14.00; p < 0.01) and multivariable-adjusted analyses [age, sex, smoking, serum alanine aminotransferase (ALT), serum hepatitis B surface antigen, anti-hepatitis C virus antibody, and T2DM] (HR = 3.82, 95% CI: 1.94, 7.52; P < 0.01). This evidence concerns the gene GPT and Obesity.