IFNs may have a key role also in vitiligo, as the treatment of different diseases using IFNs may be associated with the onset of vitiligo, notably metastatic melanoma (11), hepatitis C infections (12), or during the treatment of skin tumors with imiquimod, an IFN gamma (IFNγ)-releasing agent (13). This evidence concerns the gene IFNG and metastatic melanoma.