Furthermore, TRPV4 also regulates the integrity of the blood-cerebrospinal fluid barrier (Narita et al., 2015) and TRPV4 inhibition reduced BBB disruption and consecutive edema in a mouse model of intracerebral hemorrhage and thereby ameliorated neurological symptoms (Zhao et al., 2018). The gene discussed is TRPV4; the disease is intracerebral hemorrhage.