SPARCL1 and infection: Another interesting protein predicted to be downregulated during the infection in lung and arterial tissues is SPARC-like 1 (SPARCL-1), also known as Hevin, commonly associated with regulation of cell migration and modulation of extracellular matrix proteins (Girard and Springer, 1996), and it has been shown to be involved in lymphocyte transendothelial migration through high endothelial venules (Girard and Springer, 1995).