ZNRF3 and geroderma osteodysplastica: Most recently, Collynn and colleagues revealed that the TSHR signaling in GO patients can enhance OFs proliferation partially via induction of miR-146a and miR-155, and the effects of miR-146a and miR-155 may be due to their suppression on zinc and ring finger 3 (ZNRF3) and phosphatase and tensin homolog (PTEN) that normally limit cell proliferation (Woeller et al., 2019).