Further investigation into the molecular mechanisms suggested that SNX9 interacts directly with YAP and increases the large tumor suppressor kinase 1 (LATS1)-mediated phosphorylation of YAP, resulting in the cytoplasmic retention of YAP and the decreased transcriptional activity of YAP/TEA domain transcription factor 4 (TEAD4), which, consequently, inhibits the expression of Hippo target genes and prevents ADPKD development. Here, SNX9 is linked to autosomal dominant polycystic kidney disease.