IL6 and metastatic neoplasm: Epirubicin, although with much milder associated cardiotoxicity than other anthracyclines, is shown here to promote endothelial secretion of IL-6 and IL-8 (Childs et al., 2015), previously linked to senescence and increased tumorigenesis (Ortiz-Montero et al., 2017), which in turn may be associated with increased risk of metastatic disease.