Sox9 signaling showed to be essential in the EMT mechanism in non-small-cell lung carcinoma cell (Zhang et al., 2017; Huang et al., 2019), mouse embryonic mammary cells (Kogata et al., 2018), mouse gastric cancer cells (Li et al., 2018), human colorectal cancer cells (Choi et al., 2017), human hepatocellular carcinoma cells (Kawai et al., 2016), thyroid cancer cells (Huang and Guo, 2017), and avian neural crest cells (Sakai et al., 2006) in vitro. This evidence concerns the gene SOX9 and hepatocellular carcinoma.