VEGFC and neoplasm: Central factor of lymphangiognesis (Hsu et al., 2019). Essential for HEV formation (Furtado et al., 2007). Overexpression fosters lymphatic metastasis (Decio et al., 2014; Wang et al., 2014; Yang et al., 2014; Goussia et al., 2018). Activated LECs by VEGF-C suppress tumor specific CD8+ T cells (Lund et al., 2012).