The vasoconstrictive peptide Endothelin 1 (ET1), known for its direct effect on angiogenesis via VEGF and HIF1 (Spinella et al., 2002), is also associated with ICAM1 expression and the decreased presence of tumor infiltrating leukocytes (TIL) (Buckanovich et al., 2008). Here, HIF1A is linked to neoplasm.