HIF1A and neoplasm: Therefore, tumor angiogenesis is sustained by galectins via autocrine and paracrine mechanisms (Thijssen et al., 2010) as well as by direct interactions with VEGFR2 and HIF1α (Markowska et al., 2011; Zhao et al., 2011; Laderach et al., 2013; White et al., 2014).