Another mechanism of endothelial anergy includes the secretion of soluble adhesion molecules by tumor cells (MCAM/sCD146 and Endoglin) that indirectly inhibit TIL recruitment by competing with EC bound-receptors (Rossi et al., 2013; Stalin et al., 2016) and by direct VEGF-synergistic interactions with tumor angiogenesis (Zheng et al., 2009). This evidence concerns the gene VEGFA and neoplasm.