FLT4 and neoplasm: Glycan-binding endogenous lectins which sustain tumor angiogenesis via autocrine and paracrine signaling (Elola et al., 2018). Directly interact with VEGFR2, bFGF, VEGFR3 and associated with resistance to anti-angiogenic therapies (Markowska et al., 2010; Markowska et al., 2011; Zhao et al., 2011; Laderach et al., 2013; Chen et al., 2016).