IL6 and acute respiratory distress syndrome: Similarly, Martínez-González et al. (2013, 2014) observed that human MSCs derived from adipose tissue overexpressing the soluble IL-1 receptor type 1 (sST2) caused a decrease in histopathological changes associated with lower levels of pro-inflammatory cytokines TNF-α, IL-6, and MIP-2 (1.5 to 3-fold reduction), and 6-fold higher levels of IL-10 in models of ALI and asthma.