Exosomes derived from MSCs overexpressing pigment epithelium-derived factor (PEDF) or miR-25 showed neuroprotective effects in models of cerebral ischemia reperfusion and ischemic spinal cord by mechanisms involved in axonal preservation, such as regulation of autophagy and apoptosis or reduction of inflammation and oxidative stress (Huang X. et al., 2018; Zhao et al., 2018). The gene discussed is SERPINF1; the disease is Cerebral ischemia.