The transplantation of MSCs overexpressing the type 2 angiotensin II receptor (AT2R) increased cell migration in vitro by 3-fold, inhibited inflammation by decreasing pro-inflammatory cytokines (IL-1β and IL-6) and recovered the injured lung in a model of ALI in mice (Xu et al., 2018), while overexpression of the orphan receptor tyrosine kinase 2 (ROR2) by MSCs not only improved their ability to relieve inflammation and histopathological changes, but also increased their retention in lungs (Cai et al., 2016). The gene discussed is IL6; the disease is acute respiratory distress syndrome.