Aberrant expression or hyperactivation of this kinase contributes to tumorigenesis and progression of several tumors including cancer stem cells by stimulating proliferation, migration, angiogenesis, and CDK5 activity regulates the DNA damage pathway, chemotherapy resistance and anti-tumor immunity (Lenjisa et al., 2017; Pozo and Bibb, 2017; Shupp et al., 2017). Here, CDK5 is linked to cancer.