IFNG and leukemia: Moreover, the presence of certain biomarkers may be predictive for the functioning of effector mechanisms; e.g., sorafenib-related IL-15 production causes an increase in CD8+CD107a+IFN-γ+ T cells with features of longevity and eliminates leukemia in secondary recipients, indicating that sorafenib after HCT might be more effective through induction of IL-15-mediated metabolic reprogramming of leukemia-reactive T cells (66).