HER2 is a member of the ERBB family; activation of the HER2 can induce the self-tyrosine phosphorylation and subsequently activate several signal transduction pathways, including the Ras/MAP kinase cascade, phosphatidylinositol 3-kinase, and phospholipase C pathways, which can ultimately influence the proliferation, adhesion, differentiation, and metastasis of tumor cells (15). Here, EGFR is linked to neoplasm.