CDKL3 and esophageal squamous cell carcinoma: As a result, the high reduction of clone counts was investigated in TE-1-shCDKL3 and KYSE-150-shCDKL3 cells (Figures 1D,E, p < 0.001), which verified the significant growth inhibition of CDKL3 knockdown in colony formation of ESCC cells.