ATG5 re-expression weaken the tumor-inhibitive effect of CDKL3 knockdown in KD+OE group compared to KD+NC group (Figure 6C proliferation assays, p < 0.001, Figure 6D; colony formation, P < 0.001, Figure 6E caspase-3/7 activity assay, p < 0.001). This evidence concerns the gene CASP3 and neoplasm.