The statistically higher expressions of PLAUR, BIK, DRAM2, RNF41, STK38, ATG5, and PARP1 were measured in esophageal cancer than those in normal tissue, while statistically significant differences were also detected between ESCC and esophageal adenocarcinoma (EAC) (Figure 5E). This evidence concerns the gene DRAM2 and esophageal cancer.