Interestingly, this cell line, differently from other common breast cancer cell lines, such as MCF-7, express high levels of the immune checkpoint PD-L1 (22), which can bind to its receptor PD-1 at the surface of effector T lymphocytes, therefore acting as a brake and impairing the activation and the assemble of a proper antitumor response. Here, CD274 is linked to breast carcinoma.