It was found that a miR-181a gene target, WiF-1 (Wnt inhibitory factor 1), leads to a potent liver metastasis effect by suppressing epithelial markers such as E-cadherin and β-catenin and by overexpressing the mesenchymal marker vimentin found in CRC tumor tissues with liver metastasis (42). This evidence concerns the gene WIF1 and neoplasm.