Pericytes and endothelial cells promote intravasation, which is the process wherein cancer cells move into the blood and lymphatic flow (15); however, tumor progress for angiogenesis due to the increased expression of metalloproteases and growth factors depends on the high expression of VEGF-A and Wnt7B, which are both expressed by macrophages that co-express Tie2. The gene discussed is VEGFA; the disease is cancer.