Endothelial cells, pericytes, and TAMs contribute to tumor intravasation by performing pro-angiogenic effects; conversely, VEGF, colony-stimulating factor-1 (CSF-1), and Ang2 induce neo-vessel formation via the expression of interleukin 8 (IL-8) (5, 100) in murine cancer models. The gene discussed is VEGFA; the disease is cancer.