The transcription factor TWIST-1 has also been reported to induce miR-10b, which promotes metastasis by targeting Homeobox D10 (HOXD10), which is associated with the inhibition of cell migration and may reduce E-cadherin expression, resulting in EMT (35); this mechanism is associated with hypermethylation of the miR-10 promoter in CRC tissues; however, studies with greater samples and in different stages to know the role in CRC progression were necessary. Here, TWIST1 is linked to colorectal carcinoma.