KLF4 and neoplasm: First, miR-145 reduces the Warburg effect by KLF4 silencing in bladder cancer (65), and second, in breast cancer, miR-548a-3p targets sine oculis homeobox 1 (SIX1), which is a transcription factor that causes the Warburg effect, and miR-30a-5p targets the lactate dehydrogenase A (LDHA)-mediated Warburg effect, thereby suppressing tumor growth and metastasis (66, 67).