Another important aspect of survival is the upregulation of NF-κβ and TNFα by blocking the effects of the tumor suppresor protein DAB2IP, as p53 mutants provide activation by increasing the production of cytokines IL-6, IL-11, and IL-23 (pro-angiogenic), as well as the production of cancer cells due to cytotoxic effects happening in the environment (Figure 4). The gene discussed is TP53; the disease is cancer.