In a complex array of autocrine and paracrine functions including feedback loops, IL-8 signaling is involved in all the stages of tumor development including proliferation, angiogenesis, and inflammatory setup... Most importantly, it induces EMT in human carcinoma cells, associated with metastasis and stemness, thus increasing invasiveness and greater resistance to various cytotoxicities including immune destruction (39). This evidence concerns the gene CXCL8 and carcinoma.