TP53 and pancreatic adenocarcinoma: MB725 also showed potent and selective viability reduction of several p53-Y220C cancer cell lines such as BXPC-3 (pancreatic adenocarcinoma), HUH-7 (hepatocellular carcinoma), NUGC3 (gastric adenocarcinoma), while maintaining comparatively low toxicity in WT p53 WI38 (normal fibroblasts), and NUGC4 (gastric adenocarcinoma) in the same concentration range.