MB725 also showed potent and selective viability reduction of several p53-Y220C cancer cell lines such as BXPC-3 (pancreatic adenocarcinoma), HUH-7 (hepatocellular carcinoma), NUGC3 (gastric adenocarcinoma), while maintaining comparatively low toxicity in WT p53 WI38 (normal fibroblasts), and NUGC4 (gastric adenocarcinoma) in the same concentration range. Here, TP53 is linked to hepatocellular carcinoma.