For instance, Song et al. studied ESCC using whole genome sequencing (WGS) of 17 and whole exome sequencing (WES) of 71 ESCC samples and reported ADAM29 and FAM1335B as two significantly mutated genes along with frequently mutated genes, such as TP53, PIK3CA, NOTCH1, and NFE2L2 (13). The gene discussed is ADAM29; the disease is esophageal squamous cell carcinoma.