NOTCH1 and esophageal squamous cell carcinoma: For instance, Song et al. studied ESCC using whole genome sequencing (WGS) of 17 and whole exome sequencing (WES) of 71 ESCC samples and reported ADAM29 and FAM1335B as two significantly mutated genes along with frequently mutated genes, such as TP53, PIK3CA, NOTCH1, and NFE2L2 (13).