Thirteen genes affected by this include ATF6, DOCK5, IARS, KIAA0922, KIFAP3, MAN2B2, MBTPS1, MXRA8, NSD1, SKI, SLC12A9, TP53, and ZNF277. Expression pattern of 6 out of 13 genes (KIFAP3, MBTPS1, NSD1, SLC12A9, TP53, and ZNF277) in the TCGA-Esophageal Carcinoma (ESCA) dataset indicates overexpression in ESCC samples (n = 95) (26). This evidence concerns the gene ATF6 and esophageal squamous cell carcinoma.