TP53 (71%), TTN (64%), CSMD3 (43%), SYNE1 (28%), LRP1B (25%), PIK3CA (25%), DNAH5 (21%), and NOTCH1 (14%) were recurrently mutated genes in our ESCC cohort (Figure 1). This evidence concerns the gene SYNE1 and esophageal squamous cell carcinoma.