Studies have linked TMPRSS2 to prostate cancer via a chromosomal translocation resulting in the fusion of the TMPRSS2 promoter-enhancer with the Erythroblast Transformation Specific (ETS) transcription factors ETS-related gene (ERG) and ETS translocation variant 1 (ETV1) (13). The gene discussed is TMPRSS2; the disease is Familial prostate cancer.