Here, leveraging the recent finding by Hoffmann et al. (1) that ACE2 and TMPRSS2 are critical for SARS-CoV-2 cell entry, we discuss the potential link between the SARS-CoV-2 receptors and the prostate gland and whether SARS-CoV-2 is a potential oncogenic virus for prostate cancer. This evidence concerns the gene ACE2 and Familial prostate cancer.