TLR4 staining by immunohistochemistry (IHC) has been examined in a number of hematologic malignancies and increased expression can be demonstrated on tumor cells in diffuse large B-cell lymphoma (DLBCL), multiple myeloma, and B acute lymphoblastic leukemia (B-ALL) (33, 34). This evidence concerns the gene TLR4 and diffuse large B-cell lymphoma.