CCL4 and B-cell chronic lymphocytic leukemia: The release of CCL3 and CCL4 after coculture with NLCs (42) or MSCs (114) or after treatment with MCS-derived EVs (138) is another example showing that the consequences of microenvironmental interactions could be used as prognostic factors, since CCL3 and CCL4 levels in the plasma of CLL patients are associated with the time from diagnosis to initial therapy (121).