Interestingly, this phenomenon is coupled to the increase in VEGF, CXCL10, CCL2, IL6, intercellular adhesion molecule 1 (ICAM1) or CXCL12, which are important molecules involved in the homing of CLL cells that were previously discussed (135, 143). This evidence concerns the gene ICAM1 and B-cell chronic lymphocytic leukemia.