The function of the four ARGs that associated bad survival of NB in our study has been reported as follows: EIF4EBP1 is a downstream target of mTOR signaling pathway and could inhibit autophagy initiation (42, 43); WDR45B was found to play an essential role in maintaining neural autophagy and neural homeostasis (44); SPNS1 was found to play an important role in orchestrating autolysosomal biogenesis and is critically linked to developmental senescence and survival (45); TM9SF1 was found to play important roles in inducing autophagy (46). This evidence concerns the gene WDR45B and neuroblastoma.