The subgroups were classified according to MYCN amplification status (not amplified and amplified), histology subtype (favorable and unfavorable), differentiation status (differentiating and poorly differentiated), ploidy status (hyperdiploid and diploid), MKI status (low, intermediate and high), pathology subtype (ganglioneuroblastoma and NB), COG risk status (low and high), age status (age < 18 months and age > 18 months), and INSS stage. The gene discussed is MYCN; the disease is neuroblastoma.