Plenty of miRNA-mRNA axes, such as miR-34a-Notch1 axis (30), miR-125b-Sema4c axis (31), miR-181-Bcl-2 axis (33), and miR-27b/CBLB/GRB2 axis (34), were reported that regulated taxanes-resistance in breast cancer. Here, GRB2 is linked to breast cancer.