But the inverse association between IGF1 and all-cause mortality seemed to be more pronounced among patients who were premenopausal (HR, 0.34; 95% CI, 0.12–0.97), with a tumor size >2 cm (HR, 0.35; 95% CI, 0.17–0.73), with positive lymph node (HR, 0.49; 95% CI, 0.25–0.98), and with a high Ki-67 level (HR, 0.49; 95% CI, 0.26–0.95). The gene discussed is IGF1; the disease is neoplasm.