Therefore, in this study, we evaluated the expression of NLRP3 inflammasome on pancreatic cancer cells and showed that each component of NLRP3 inflammasome was expressed on both human pancreatic cell lines SW1990 and PANC-1, confirming the relationship between NLRP3 inflammasome and pancreatic cancer. This evidence concerns the gene NLRP3 and familial pancreatic carcinoma.