However, downregulation of AAK or expression of mutant S165A FANCA sensitizes tumor cells to mitomycin C. Since CP is a DNA cross linking agent and the OC2 as well as UPN251 cells do not harbor BRCA1/BRCA2 mutations, the enhanced cytotoxicity with CP/AL could be related to inhibition of AAK activation of the Fanconi anemia/BRCA repair pathway by AL. The gene discussed is BRCA2; the disease is Fanconi anemia.