To further investigate the relationship between p53 and PGC1α in NSCLC cells, we examined the expression of PGC1α in cells with different variants of p53, that is, A549 (p53 wild type), H1975 (p53 mutant), and H1299 (p53-null). The gene discussed is PPARGC1A; the disease is non-small cell lung carcinoma.