CHUK and neoplasm: We previously found that downregulation of cyclooxygenase-1 (COX-1) expression, an established pro-tumor mediator in ovarian cancer, resulted in reduced expression of multiple non-canonical NF-κB signaling components, including RELB, NFKB2 (p100/p52), CHUK (IKKα), and MAP3K14 (NF-κB-inducing kinase); in contrast, expression of canonical NF-κB pathway members was not changed by COX-1 knockdown [57].