APC and cancer: Other genes, including DACT2, SOX17, CDX2, NKD2, HIN1, IGFBPL1, TMEM176A, HOXD10, SFRP1, GATA4, GATA5, CDH1, APC, DACH1, were reported frequently methylated and indirectly involved in cell cycle regulation through Wnt, PI3K-AKT, ERK, TGF-beta and other signaling pathways in different cancers [113, 133–140].