Methylation of WRN was found in 37.9% of colorectal cancer (CRC), 37.5% of non-small cell lung cancer (NSCLC), 25% of gastric, 20% of prostate, 17.2% of breast, 12.5% of thyroid cancer, 23.7% of non-Hodgkin lymphoma, 9.5% of acute lymphoblastic leukemia, 4.8% of acute myeloblastic leukemia, 33.3% of chondrosarcomas and 11.1% of osteosarcomas. This evidence concerns the gene WRN and non-small cell lung carcinoma.