The first of these asked 60 healthy volunteers to complete a simulated public speaking test after pre-treatment with either CBD (100, 300 and 900 mg), clonazepam (1 mg) or placebo.16 In the second, 57 healthy volunteers completed a similar task after pre-treatment with a single dose of either CBD (150, 300, 600 mg) or placebo.17 In both studies, only the 300 mg dose of CBD reduced anxiety symptoms. The gene discussed is OPN1MW; the disease is Anxiety.