Smaller decline on MMSE was also observed with the use of omega-3associated with ALA in mild AD (3,000 mg of omega-3+600 mg of ALA perday)37 and the use of seaweed-derived DHA (2,000 mg per day, 45‒55% of DHA)has shown to be beneficial for patients with negative Apoliprotein E (APOE)ε4 allele, being able to reduce the cognitive decline assessed byADAS-cog.36 Here, APOE is linked to Alzheimer disease.