In the search for newer and simpler biomarkers, CSF neurofilament light chain (NfL)was studied in 2019, in a cognitive clinical setting and was found to besignificantly increased in MCI, FTD, and DAT patients compared to normal controls.Interestingly, ROC curve analysis showed the highest area under the curve (AUC)value when comparing CSF NfL in control versus FTD patients, makingit a promising biomarker of neurodegeneration.27 The gene discussed is NEFL; the disease is frontotemporal dementia.