Furthermore, MYCN amplification has been reported to correlate with a high tumor vascularity [21] and it has been demonstrated that NB expresses an up-regulation of macrophage migration inhibitory factor (MIF) which is able to promote the expression of MYCN, via ERK activity, and the secretion of IL-8 and of angiogenic factors [22]. The gene discussed is MIF; the disease is neuroblastoma.