The other tyrosine kinase IL-12 signaling gene TYK2 was also significantly associated with BC risk, with SNP rs280500 increasing BC risk under the allelic (crude OR 1.36, 95% CI: 1.03–1.79, P = 0.03), additive (crude OR 1.35, 95% CI: 1.03–1.77, P = 0.02) and recessive (crude OR 2.10, 95% CI: 1.06–4.39, P = 0.04) models (Table 2). Here, TYK2 is linked to breast cancer.