Although FGF7-treated mice showed tendency to form more HFs (10.00 ± 1.45 per one vertical section) than control mice (7.86 ± 1.32 per one vertical section) without statistical significance, HF diameter (36.22 μm ± 4.79) was smaller than that of control mice (52.29 μm ± 5.50) (Fig. 4c). The gene discussed is FGF7; the disease is Hand-foot syndrome.