SREBF1 and metabolic dysfunction-associated steatotic liver disease: Exercise regulated lipid metabolism in parallel with an improvement in NAFLD, as was shown in a study in which rats with NAFLD received 6 weeks of training.18 After these 6 weeks of training, the improved liver histology was accompanied by reductions in the hepatic mRNA expression of gene-encoding enzymes involved in lipogenesis, such as sterol regulatory element-binding protein 1c (Srebp1c), CCAAT/enhancer-binding protein alpha (Cebpa) and the fatty-acid transporter (Cd36).