This liver-specific positive effect of exercise may be related to a rapid improvement in insulin sensitivity and lipid metabolism; yet, the exact mechanisms are unclear.14 International guidelines for obese and patients with NAFLD recommend similar amounts of physical activity as a treatment for NAFLD compared with physical activity guidelines for a healthy population.9,10,12,13 Current recommendations for physical activity for treatment of NAFLD and obesity according to the different international guidelines are presented in Table 1. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.