A subset of patients with CRC, who manifest the MMR deficiency but have no identified germline pathogenic variant in either MMR genes or the BRAF gene (absence of MLH1 methylation), have been defined as having Lynch-like syndrome (LLS) (Hampel et al., 2005; Rodríguez-Soler et al., 2013; Win et al., 2015). Here, MRC1 is linked to mismatch repair cancer syndrome 1.