Zhang B. et al. (2018) reported on IRGs, specifically that TSPAN15 interacts with BTRC to promote esophageal squamous cell carcinoma metastasis by activating NF-κB signaling and indicated that TSPAN15 may serve as a new biomarker and/or provide a novel therapeutic target for patients with OSCC. This suggests that IRGs can be used as prognostic biomarkers. To study the underlying mechanisms of EC development, we constructed an IRG-TF regulatory network and found 27 TFs related to prognostic genes; among them, NR2F2 is both an IRG and TF and is involved in transcriptional regulation. The gene discussed is TSPAN15; the disease is esophageal squamous cell carcinoma.