The top 10 genes were KIF18B, BIRC5, CDC20, CDCA5, MKI67, TPX2, NCAPG, MAD2L1, NEK2, and KIF4A. KIF18B had the highest MCC value and is deemed as the hub gene of ccRCC as a result. The gene discussed is KIF18B; the disease is nonpapillary renal cell carcinoma.