DEGs analysis found that KIF18B was up-regulated in ccRCC patients compared with normal control and OS analysis revealed a worse prognostic outcome in patients with high expression level of KIF18B. Correlation analysis between the expression of KIF18B and clinical traits proved that the expression of KIF18B is significantly related to tumor grade, pathological stage, T stage, and distant metastasis. The gene discussed is KIF18B; the disease is neoplasm.