The top 10 genes were KIF18B, BIRC5, CDC20, CDCA5, MKI67, TPX2, NCAPG, MAD2L1, NEK2, and KIF4A. KIF18B had the highest MCC value and is deemed as the hub gene of ccRCC as a result. This evidence concerns the gene TPX2 and nonpapillary renal cell carcinoma.