Finally, in order to explore the function and clinical significance of KIF18B, we analyzed the correlation between the expression level of KIF18B and targets of precise therapies and found the expression level of KIF18B is correlated with that of PDL1 and VEGFR3. Meanwhile, single-gene GSEA revealed that KIF18B is mainly involved in DNA replication and mutation in ccRCC. This evidence concerns the gene CD274 and nonpapillary renal cell carcinoma.